肿瘤微环境
免疫疗法
免疫系统
癌症研究
卵巢癌
巨噬细胞
趋化因子
肿瘤相关巨噬细胞
癌症
转移
医学
癌症免疫疗法
免疫学
生物
内科学
体外
生物化学
作者
David Schweer,Annabel M. McAtee,Khaga R. Neupane,Christopher I. Richards,Frederick R. Ueland,Jill Kolesar
出处
期刊:Cancers
[MDPI AG]
日期:2022-04-29
卷期号:14 (9): 2220-2220
被引量:52
标识
DOI:10.3390/cancers14092220
摘要
The tumor microenvironment (TME) has been implicated to play an important role in the progression of ovarian cancer. One of the most important components of the TME is tumor associated macrophages (TAMs). Phenotypically, macrophages are broadly categorized as M1 pro-inflammatory or M2 anti-inflammatory, based on the cytokines and chemokines that they secrete. The tumor microenvironment is associated with macrophages of an M2 phenotype which suppress the surrounding immune environment, assist tumor cells in evading immune targeting, and support tumor growth and metastasis. Contrarily, M1 macrophages help mount an immune response against tumors, and are associated with a more favorable prognosis in solid tumors. One of the characteristic indicators of a poor prognosis in ovarian cancer is the overrepresentation of M2-type TAMs. As such, therapeutic modalities targeting TME and TAMs are of increasing interest. Pharmacological approaches to eliminate TAMs, include decreasing macrophage survival and recruitment and increasing phagocytosis, have been underwhelming. Clinical strategies targeting these macrophage subtypes via repolarization to an M1 antitumoral state deserve increasing attention, and may serve as a new modality for immunotherapy.
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