粘蛋白
胃肠道
势垒函数
炎症
医学
疾病
免疫学
生物信息学
癌症研究
生物
细胞生物学
病理
内科学
作者
Tom Breugelmans,Baptiste Oosterlinck,Wout Arras,Hannah Ceuleers,Joris De Man,Georgina L. Hold,Benedicte Y. De Winter,Annemieke Smet
标识
DOI:10.1016/s2468-1253(21)00431-3
摘要
Mucins are the gatekeepers of the mucosal barrier of the gastrointestinal tract and are aberrantly expressed in various gastrointestinal pathologies, including pathogen infection, inflammation, and uncontrolled growth and spread of abnormal cells. Although several studies have emphasised the role of mucins in dysfunction of the gastrointestinal mucosal barrier, they are often still considered to be passive mediators of this barrier instead of regulators or modulators. In this Review, we discuss the interactions between mucins and gastrointestinal barrier function during health and disease. We will focus on the bidirectional relationship between mucins and the gut microbiota and will also address the molecular mechanisms involved in key cell signalling pathways, such as inflammation, cell interactions, and cell differentiation, proliferation, and survival. Additionally, we highlight the potential use of mucins in the diagnosis, follow-up, and treatment of gastrointestinal diseases, such as chronic inflammatory diseases and cancer.
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