Medical Treatment of Benign Prostatic Hyperplasia

In this article, we review the primary medical treatments of BPH-associated male LUTS, with a focus on physiology, indications, and side effects. We cover selective alpha-1 antagonists, anticholinergics, PDE5 inhibitors, 5-alpha reductase inhibitors, and beta-3 agonists. Through a review of the literature, we provide our clinical pathway for the medical management of BPH, generally starting with tamsulosin in most men and progressing to combination therapy based on patient's response and symptoms.