皂甙
细胞毒性
化学
铁线莲
毛茛科
水解
三萜类
传统医学
生药学
碱性水解
萜烯
三萜皂苷
立体化学
MTT法
酸水解
糖苷
三萜
IC50型
体外
生物化学
生物活性
植物
生物
医学
草药
草本植物
替代医学
病理
作者
Qian Zhang,Yang Lu,Yang Liu,Haifeng Tang
出处
期刊:Fitoterapia
[Elsevier]
日期:2022-06-01
卷期号:159: 105179-105179
被引量:3
标识
DOI:10.1016/j.fitote.2022.105179
摘要
Three new triterpenoid saponins, heracleifolianosides A-C (1-3), together with seven known compounds (4-10), were isolated from the whole plants of Clematis heracleifolia. Moreover, three new secondary saponins (1a, 2a and 3a), two known secondary metabolites (5a and 7a) were obtained by alkaline hydrolysis. Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. The cytotoxicity of eight native saponins and five prosapogenins against human breast tumor MDA-MB-231 and gastric carcinoma SGC-7901 cell lines were evaluated by MTT method. Remarkably, the prosapogenin monodesmosidic saponin 7a showed significant cytotoxicity against MDA-MB-231 or SGC-7901 cell lines with IC50 values in the range of 6.05-6.32 μmol/L. It is suggested that it might be a feasible way to change the inactive bisdesmosic triterpenoid saponins to active monodesmosic saponins by a simple procedure of alkaline hydrolysis.
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