亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

The impact of station 4L lymph node dissection on short-term and long-term outcomes in non-small cell lung cancer

医学 解剖(医学) 淋巴结 倾向得分匹配 内科学 淋巴 肺癌 肿瘤科 阶段(地层学) 纵隔淋巴结 子群分析 逻辑回归 泌尿科 外科 癌症 置信区间 病理 转移 古生物学 生物
作者
Yang Wo,Yuan Li,Yang Zhang,Yizhou Peng,Zhigang Wu,Pengcheng Liu,Yan Shang,Hong Hu,Yawei Zhang,Jiaqing Xiang,Yihua Sun
出处
期刊:Lung Cancer [Elsevier]
卷期号:170: 141-147 被引量:8
标识
DOI:10.1016/j.lungcan.2022.06.018
摘要

Objective The optimal extent of lymph node dissection (LND) remains controversial. We aimed to investigate whether the addition of station 4L lymph node dissection (S4L-LND) was beneficial for non-small cell lung cancer (NSCLC). Methods Data on 1040 left-sided NSCLC patients undergoing rigorous systematic LND were retrospectively reviewed. Multivariate logistic regression analysis determined risk factors of station 4L (S4L) nodal involvement to facilitate risk stratified analysis of the significance of S4L-LND. Propensity score matching (PSM) was conducted to reduce disparities of baseline characteristics between S4L-LND group and no-S4L-LND group. Recurrence-free survival (RFS), overall survival (OS), and postoperative complications were compared. Results S4L-LND was performed in 586 (56.3%) patients. The S4L nodal involvement rate was 15.5% (91/586). Aortopulmonary zone nodes involvement (P < 0.001), N1 nodes involvement (P < 0.001), and advanced T stage (P = 0.015) were independent risk factors of S4L nodal involvement. Patients with ≥ 2 risk factors of S4L nodal involvement were classified as high risk group, and the others were classified as low risk group. Among patients with negative aortopulmonary zone nodes and inferior mediastinal nodes (n = 425), only 28 (6.6%) patients had S4L involvement. After PSM, a total of 416 pairs were well matched. There was no significant survival difference between S4L-LND group and no-S4L-LND group (OS, P = 0.247; RFS, P = 0.569). When stratified by risk subgroup, S4L-LND group did not demonstrate superior survival than no-S4L-LND group in the high risk group (OS, P = 0.273; RFS, P = 0.754) or the low risk group (OS, P = 0.558; RFS, P = 0.319). S4L-LND group demonstrated significantly greater risk of postoperative complications than no-S4L-LND group (9.6% vs. 5.8%; P = 0.037). Conclusions S4L involvement was not rare and usually occurred with multiple nodal stations involvement. Routine dissection of aortopulmonary zone and inferior mediastinal nodes was sufficient to ensure staging accuracy. The addition of S4L-LND did not improve survival, but might increase the risk of postoperative complications.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
efren1806完成签到,获得积分10
25秒前
2分钟前
天行健完成签到,获得积分10
2分钟前
陆林北完成签到,获得积分10
3分钟前
3分钟前
3分钟前
4分钟前
小韩同学完成签到,获得积分10
4分钟前
5分钟前
5分钟前
6分钟前
6分钟前
小牛发布了新的文献求助10
6分钟前
6分钟前
小牛完成签到,获得积分10
7分钟前
Wang完成签到 ,获得积分20
7分钟前
7分钟前
neurology完成签到,获得积分10
7分钟前
neurology发布了新的文献求助10
7分钟前
wtsow完成签到,获得积分0
7分钟前
7分钟前
8分钟前
田様应助科研通管家采纳,获得10
8分钟前
9分钟前
淡淡的幻然关注了科研通微信公众号
9分钟前
9分钟前
9分钟前
非洲大象完成签到,获得积分10
9分钟前
hzc应助科研通管家采纳,获得10
10分钟前
10分钟前
别找了睡觉吧完成签到 ,获得积分10
10分钟前
11分钟前
hzc应助科研通管家采纳,获得10
12分钟前
hzc应助科研通管家采纳,获得10
12分钟前
hzc应助科研通管家采纳,获得10
12分钟前
12分钟前
冷安发布了新的文献求助10
12分钟前
Chenmengdan应助wangsiheng采纳,获得10
13分钟前
13分钟前
zydd发布了新的文献求助10
14分钟前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3081574
求助须知:如何正确求助?哪些是违规求助? 2734422
关于积分的说明 7532772
捐赠科研通 2383886
什么是DOI,文献DOI怎么找? 1264087
科研通“疑难数据库(出版商)”最低求助积分说明 612563
版权声明 597578