PRC2
多组蛋白
染色质
组蛋白H3
生物
组蛋白
遗传学
细胞生物学
基因
抑制因子
基因表达
作者
Katerina Kraft,Kathryn E. Yost,Sedona E. Murphy,Andreas Magg,Yicheng Long,M. Ryan Corces,Jeffrey M. Granja,Lars Wittler,Stefan Mundlos,Thomas R. Cech,Alistair N. Boettiger,Howard Y. Chang
标识
DOI:10.1073/pnas.2201883119
摘要
Significance The relationship between long-range Polycomb-associated chromatin contacts and the linear propagation of histone H3 lysine 27 trimethylation (H3K27me3) by Polycomb repressive complex 2 (PRC2) is not well-characterized. Here, we nominate a role for developmental loci as genomic architectural elements that enable long-range spreading of H3K27me3. Polycomb-associated loops are disrupted upon loss of PRC2 binding and deletion of loop anchors results in alterations of H3K27me3 deposition and ectopic gene expression. These results suggest that Polycomb-mediated genome architecture is important for gene repression during embryonic development.
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