亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Prognostic Implications of Raphe in Bicuspid Aortic Valve Anatomy

医学 二尖瓣 心脏病学 内科学 中缝 解剖 主动脉瓣 5-羟色胺能 受体 血清素
作者
William Kong,Victoria Delgado,Kian Keong Poh,Madelien V. Regeer,Arnold C.T. Ng,Louise McCormack,Tiong Cheng Yeo,Miriam Shanks,Sarah Parent,Roxana Enache,Bogdan A. Popescu,Michael Liang,James Yip,Charlotte Lawrence,Vasileios Kamperidis,Philippe J. van Rosendael,Enno T. van der Velde,Nina Ajmone Marsan,Jeroen J. Bax
出处
期刊:JAMA Cardiology [American Medical Association]
卷期号:2 (3): 285-285 被引量:121
标识
DOI:10.1001/jamacardio.2016.5228
摘要

Little is known about the association between bicuspid aortic valve (BAV) morphologic findings and the degree of valvular dysfunction, presence of aortopathy, and complications, including aortic valve surgery, aortic dissection, and all-cause mortality.To investigate the association between BAV morphologic findings (raphe vs nonraphe) and the degree of valve dysfunction, presence of aortopathy, and prognosis (including need for aortic valve surgery, aortic dissection, and all-cause mortality).In this large international multicenter registry of patients with BAV treated at tertiary referral centers, 2118 patients with BAV were evaluated. Patients referred for echocardiography from June 1, 1991, through November 31, 2015, were included in the study.Clinical and echocardiographic data were analyzed retrospectively. The morphologic BAV findings were categorized according to the Sievers and Schmidtke classification. Aortic valve function was divided into normal, regurgitation, or stenosis. Patterns of BAV aortopathy included the following: type 1, dilation of the ascending aorta and aortic root; type 2, isolated dilation of the ascending aorta; and type 3, isolated dilation of the sinus of Valsalva and/or sinotubular junction.Association between the presence and location of raphe and the risk of significant (moderate and severe) aortic valve dysfunction and aortic dilation and/or dissection.Of the 2118 patients (mean [SD] age, 47 [18] years; 1525 [72.0%] male), 1881 (88.8%) had BAV with fusion raphe, whereas 237 (11.2%) had BAV without raphe. Bicuspid aortic valves with raphe had a significantly higher prevalence of valve dysfunction, with a significantly higher frequency of aortic regurgitation (622 [33.1%] vs 57 [24.1%], P < .001) and aortic stenosis (728 [38.7%] vs 51 [21.5%], P < .001). Furthermore, aortic valve replacement event rates were significantly higher among patients with BAV with raphe (364 [19.9%] at 1 year, 393 [21.4%] at 2 years, and 447 [24.4%] at 5 years) vs patients without raphe (30 [14.0%] at 1 year, 32 [15.0%] at 2 years, and 40 [18.0%] at 5 years) (P = .02). In addition, the all-cause mortality event rates were significantly higher among patients with BAV with raphe (77 [5.1%] at 1 year, 87 [6.2%] at 2 years, and 110 [9.5%] at 5 years) vs patients without raphe (2 [1.8%] at 1 year, 3 [3.0%] at 2 years, and 5 [4.4%] at 5 years) (P = .03). However, on multivariable analysis, the presence of raphe was not significantly associated with all-cause mortality.In this large multicenter, international BAV registry, the presence of raphe was associated with a higher prevalence of significant aortic stenosis and regurgitation. The presence of raphe was also associated with increased rates of aortic valve and aortic surgery. Although patients with BAV and raphe had higher mortality rates than patients without, the presence of a raphe was not independently associated with increased all-cause mortality.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
林子青完成签到,获得积分10
14秒前
核桃发布了新的文献求助30
23秒前
李健应助reerwt采纳,获得10
31秒前
32秒前
ICSSCI发布了新的文献求助10
37秒前
40秒前
刘宇童给刘宇童的求助进行了留言
42秒前
reerwt发布了新的文献求助10
46秒前
48秒前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
ICSSCI完成签到,获得积分10
1分钟前
1分钟前
董可以发布了新的文献求助10
1分钟前
风华正茂完成签到,获得积分10
2分钟前
2分钟前
2分钟前
jimmy_bytheway完成签到,获得积分0
2分钟前
桃桃发布了新的文献求助10
2分钟前
可爱的函函应助桃桃采纳,获得10
2分钟前
2分钟前
2分钟前
2分钟前
3分钟前
NexusExplorer应助科研通管家采纳,获得10
3分钟前
所所应助爱笑的毛衣采纳,获得10
3分钟前
3分钟前
3分钟前
duan完成签到 ,获得积分10
3分钟前
holder完成签到,获得积分10
4分钟前
4分钟前
沐白发布了新的文献求助10
4分钟前
4分钟前
刘宇童发布了新的文献求助10
4分钟前
大模型应助吕易巧采纳,获得10
4分钟前
迷人问兰完成签到,获得积分10
4分钟前
闪闪映易完成签到 ,获得积分10
4分钟前
4分钟前
吕易巧发布了新的文献求助10
4分钟前
吕易巧完成签到,获得积分10
4分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990049
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256354
捐赠科研通 3270976
什么是DOI,文献DOI怎么找? 1805166
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228