Are Markers of Systemic Inflammation Good Prognostic Indicators in Colorectal Cancer?

医学 结直肠癌 内科学 肿瘤科 贝伐单抗 阶段(地层学) 中性粒细胞与淋巴细胞比率 癌症 全身炎症 疾病 转移 炎症 化疗 淋巴细胞 生物 古生物学
作者
Sabrina Rossi,Michele Basso,Antonia Strippoli,Giovanni Schinzari,Ettore D’Argento,Mario Larocca,Alessandra Cassano,Carlo Barone
出处
期刊:Clinical Colorectal Cancer [Elsevier BV]
卷期号:16 (4): 264-274 被引量:95
标识
DOI:10.1016/j.clcc.2017.03.015
摘要

Systemic inflammation has been proved to play a crucial role in promoting cancer progression and metastasis in many cancer types, including colorectal cancer (CRC). The aim of the present review was to provide an overview of studies regarding the prognostic value of inflammation-based markers in patients with CRC. A literature search was performed for articles reporting the prognostic value of the Glasgow prognostic score (GPS), modified GPS (mGPS), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in relation to CRC outcomes. In resectable early-stage CRC, high GPS scores seem significantly associated with cancer-specific survival. It has also been suggested that adjuvant chemotherapy for stage II CRC could improve cancer-specific survival in patients with high GPS scores. In patients with both resectable and unresectable metastatic CRC and a higher GPS score, all studies suggested poorer overall survival. In early-stage and resectable metastatic CRC, the NLR seemed related to overall survival; however, the data for disease-free survival were discordant. In metastatic disease, a possible correlation between a greater NLR and poorer response to bevacizumab has been suggested. Data concerning the prognostic and predictive role of the PLR and LMR in CRC are to date insufficient. In patients with unresectable metastatic disease, inflammation markers can be used to predict the chemotherapeutic outcome and monitor tumor progression. However, further prospective studies might lead to better risk stratification for patients eligible for curative surgery, thus, allowing the restriction of neoadjuvant and adjuvant therapy to patients with high-risk CRC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
IanYoung71发布了新的文献求助10
刚刚
刚刚
2秒前
养菌人完成签到,获得积分10
2秒前
2秒前
Dritsw应助labxgr采纳,获得10
2秒前
wanci应助忧虑的代容采纳,获得50
3秒前
凯凯完成签到,获得积分10
3秒前
JS发布了新的文献求助10
4秒前
烟花应助学术裁缝采纳,获得10
4秒前
5秒前
EasonYan发布了新的文献求助10
5秒前
dypdyp应助ZH采纳,获得10
5秒前
东日发布了新的文献求助10
5秒前
Leilei完成签到,获得积分20
5秒前
呆萌代桃发布了新的文献求助10
5秒前
万能图书馆应助yan123采纳,获得10
6秒前
小二郎应助俊逸的代曼采纳,获得10
6秒前
7秒前
呼呼哈哈完成签到,获得积分10
7秒前
D5发布了新的文献求助10
7秒前
勤奋的绪发布了新的文献求助10
8秒前
xiaxue发布了新的文献求助10
9秒前
9秒前
mojinzhao完成签到,获得积分10
10秒前
明天见完成签到,获得积分10
10秒前
TMOMOR应助小赵采纳,获得10
11秒前
hh完成签到 ,获得积分10
12秒前
CipherSage应助ZHQ采纳,获得10
12秒前
我不是很帅完成签到,获得积分10
12秒前
13秒前
JosephLee发布了新的文献求助10
13秒前
13秒前
13秒前
华西招生版完成签到,获得积分10
14秒前
14秒前
xxxxfiona发布了新的文献求助10
14秒前
16秒前
16秒前
情殇发布了新的文献求助10
16秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969458
求助须知:如何正确求助?哪些是违规求助? 3514286
关于积分的说明 11173363
捐赠科研通 3249652
什么是DOI,文献DOI怎么找? 1794948
邀请新用户注册赠送积分活动 875501
科研通“疑难数据库(出版商)”最低求助积分说明 804836