Efficacy and safety of solifenacin in the treatment of overactive bladder

Objective To evaluate the efficacy and safety of solifenacin in patients with overactive bladder （OAB）. Methods A multicenter clinical trial was conduced. 216 patients with OAB were enrolled. All the patients received solifenacin（5 mg once daily）. With 5 weeks＇treatment, all the patients recorded the diary and the adverse events as well. The symptoms of urgency, frequency, nocturia, urine volume, incontinence were evaluated. The results of the efficacy and safety were analyzed by using SPSS 13. 0. Results After 5 week treatments, all the index obviously improved（P〈0.05）. 187 cases （86.7%）were cured and 43 cases recovered normal voiding, 29 cases improved obviously. 11cases（5.0 %）reported adverse effect as dry mouth, dry eye. Conclusion Solifenacin could be the safe and effective drug in the treatment of OAB patients. Key words: Overactive bladder;  Solifenacin;  Clinical trials