毒力
超抗原
蛋白酵素
金黄色葡萄球菌
微生物学
溶血素
生物
响应调节器
双组分调节系统
细菌
基因
遗传学
细菌蛋白
生物化学
酶
突变体
作者
Qian Liu,Won Sik Yeo,Taeok Bae
出处
期刊:Genes
[MDPI AG]
日期:2016-10-03
卷期号:7 (10): 81-81
被引量:150
摘要
In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS two-component system (TCS) plays a major role in controlling the production of over 20 virulence factors including hemolysins, leukocidins, superantigens, surface proteins, and proteases.The SaeRS TCS is composed of the sensor histidine kinase SaeS, response regulator SaeR, and two auxiliary proteins SaeP and SaeQ.Since its discovery in 1994, the sae locus has been studied extensively, and its contributions to staphylococcal virulence and pathogenesis have been well documented and understood; however, the molecular mechanism by which the SaeRS TCS receives and processes cognate signals is not.In this article, therefore, we review the literature focusing on the signaling mechanism and its interaction with other global regulators.
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