Cytokine profiling for prediction of symptomatic radiation-induced lung injury

医学 细胞因子 肿瘤坏死因子α 胃肠病学 单核细胞 白细胞介素6 粒细胞巨噬细胞集落刺激因子 内科学 粒细胞 放射治疗 白细胞介素 免疫学 肿瘤科 病理
作者
Justin P. Hart,Gloria Broadwater,Zahid N. Rabbani,Benjamin J. Moeller,Robert Clough,Dale Huang,Gregory D. Sempowski,Mark W. Dewhirst,Salvatore V. Pizzo,Željko Vujašković,Mitchell S. Anscher
出处
期刊:International Journal of Radiation Oncology Biology Physics [Elsevier]
卷期号:63 (5): 1448-1454 被引量:83
标识
DOI:10.1016/j.ijrobp.2005.05.032
摘要

To analyze plasma cytokine profiles before the initiation of radiation therapy to define a cytokine phenotype that correlates with risk of developing symptomatic radiation-induced lung injury (SRILI).Symptomatic radiation-induced lung injury was evaluated in 55 patients (22 with SRILI and 33 without SRILI), according to modified National Cancer Institute common toxicity criteria. These plasma samples were analyzed by the multiplex suspension bead array system (Bio-Rad Laboratories; Hercules, CA), which included the following cytokines: interleukin (IL)-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-13, IL-17, granulocyte/macrophage colony-stimulating factor, interferon-gamma, monocyte chemotactic protein 1, macrophage inflammatory protein 1beta, tumor necrosis factor alpha, and granulocyte colony-stimulating factor.Significant differences in the median values of IL-8 were observed between patients with and without SRILI. Patients who did not develop SRILI had approximately fourfold elevated levels of IL-8 as compared with patients who did subsequently develop SRILI. Significant correlations were not found for any other cytokine in this study, including transforming growth factor beta1.Patients with lower levels of plasma IL-8 before radiation therapy might be at increased risk for developing SRILI. Further studies are necessary to determine whether IL-8 levels are predictive of SRILI in a prospective trial and whether this marker might be used to determine patient eligibility for dose escalation.
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