类固醇
珊瑚
生物
细胞毒性
立体化学
植物
癌细胞系
化学
生物化学
癌细胞
激素
癌症
体外
生态学
遗传学
作者
Ioanna Kontiza,Dennis Abatis,Katerina Malakate,Constantinos Vagias,Vassilios Roussis
出处
期刊:Steroids
[Elsevier]
日期:2005-11-09
卷期号:71 (2): 177-181
被引量:61
标识
DOI:10.1016/j.steroids.2005.09.004
摘要
The new (20R)-22E-cholesta-4,22-diene-3,6-dione (1), along with three known 3-keto steroids were isolated from the deep-water Mediterranean scleractinian coral Dendrophyllia cornigera (2–4). Moreover, four known related 3-keto steroids were isolated from the sea grass Cymodocea nodosa (5–8). The structure elucidation of steroid 1 and the full NMR resonance assignments of all isolated metabolites were based on interpretation of their spectral data. All compounds are reported for the first time as metabolites of the investigated organisms. Compounds 2 and 3 showed significant cytotoxicity against lung cancer NSCLC-N6 cell line.
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