MMP-9 is predominantly expressed in epithelioid and not spindle cell uveal melanoma

基质金属蛋白酶 黑色素瘤 细胞外基质 静脉注射 葡萄膜 上皮样细胞 病理 医学 癌症研究 癌症 转移 免疫组织化学 生物 内科学 细胞生物学
作者
Yosuf El‐Shabrawi,Neda Ardjomand,H. Radner,Navid Ardjomand
标识
DOI:10.1002/1096-9896(200106)194:2<201::aid-path840>3.0.co;2-o
摘要

Extracellular matrix-degrading enzymes are crucial for cancer metastases. One group of enzymes that has been increasingly implicated in the breakdown of the extracellular matrix, and hence the intravasation and dissemination of tumour cells, is the family of metalloproteinases. In the recent past, increasing efforts have led to the development of more or less specific matrix metalloproteinase (MMP) inhibitors. Data concerning the molecular nature and timing of the contribution of MMPs to tumour spread is of paramount importance in clarifying which MMP is an appropriate target for more selective MMP inhibition in future tumour therapy. This study immunohistochemically characterized the expression pattern of MMP-2, -3, and -9 in 26 uveal melanomas. Forty-six per cent of the uveal melanomas expressed MMP-2 and/or MMP-9. MMP-3 expression was seen in 17 out of 26 uveal melanomas. MMP-9, previously shown to play an important part in tumour dissemination, was predominantly present in epithelioid melanomas (71.4%) or the epithelioid portion of mixed cell uveal melanomas (67%), whereas only one out of ten spindle cell melanomas showed MMP-9 expression (10%). MMP-2 and MMP-9 expression was associated with a significantly higher incidence of metastatic disease. The survival rate of patients with MMP-2-positive melanomas was 31% vs. 85% for patients with MMP-2-negative (p<0.05); for MMP-9-positive uveal melanomas the survival rate was 27% vs. 85% with MMP-9-negative uveal melanomas (p<0.04). The fact that patients suffering from TIMP-1- as well as TIMP-2-positive uveal melanomas tended to show a better survival rate (72% vs. 45% for TIMP-1; 88% vs. 37% for TIMP-2) supports the view that proteolytic enzymes are of importance in tumour spread.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
勤奋的如松完成签到,获得积分0
1秒前
粥可温完成签到,获得积分10
3秒前
曾珍发布了新的文献求助10
4秒前
5秒前
hzh完成签到 ,获得积分10
6秒前
gg发布了新的文献求助10
6秒前
勤劳滑板完成签到 ,获得积分10
6秒前
Jerry完成签到,获得积分10
7秒前
MrLiu完成签到,获得积分10
8秒前
冷傲博完成签到,获得积分10
8秒前
jeff完成签到,获得积分10
8秒前
LHZ完成签到,获得积分10
8秒前
所所应助时尚俊驰采纳,获得10
9秒前
影子芳香完成签到 ,获得积分10
10秒前
11秒前
11秒前
不必要再讨论适合与否完成签到,获得积分0
12秒前
无情夏寒完成签到 ,获得积分10
13秒前
慕青应助马士全采纳,获得10
14秒前
xuzj应助科研通管家采纳,获得10
14秒前
Rubby应助科研通管家采纳,获得30
15秒前
SciGPT应助科研通管家采纳,获得10
15秒前
15秒前
15秒前
shiizii应助科研通管家采纳,获得10
15秒前
15秒前
15秒前
15秒前
ludong_0应助科研通管家采纳,获得10
15秒前
YeeYee发布了新的文献求助10
15秒前
冷酷的松思完成签到,获得积分10
15秒前
zgt01发布了新的文献求助10
16秒前
zhang完成签到,获得积分10
16秒前
江中完成签到 ,获得积分10
18秒前
18秒前
阿玖完成签到 ,获得积分10
19秒前
jiaolulu发布了新的文献求助10
21秒前
踏雪飞鸿完成签到,获得积分10
22秒前
hannah完成签到,获得积分10
22秒前
songvv发布了新的文献求助10
23秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022