MMP-9 is predominantly expressed in epithelioid and not spindle cell uveal melanoma

基质金属蛋白酶 黑色素瘤 细胞外基质 静脉注射 葡萄膜 上皮样细胞 病理 医学 癌症研究 癌症 转移 免疫组织化学 生物 内科学 细胞生物学
作者
Yosuf El‐Shabrawi,Neda Ardjomand,H. Radner,Navid Ardjomand
标识
DOI:10.1002/1096-9896(200106)194:2<201::aid-path840>3.0.co;2-o
摘要

Extracellular matrix-degrading enzymes are crucial for cancer metastases. One group of enzymes that has been increasingly implicated in the breakdown of the extracellular matrix, and hence the intravasation and dissemination of tumour cells, is the family of metalloproteinases. In the recent past, increasing efforts have led to the development of more or less specific matrix metalloproteinase (MMP) inhibitors. Data concerning the molecular nature and timing of the contribution of MMPs to tumour spread is of paramount importance in clarifying which MMP is an appropriate target for more selective MMP inhibition in future tumour therapy. This study immunohistochemically characterized the expression pattern of MMP-2, -3, and -9 in 26 uveal melanomas. Forty-six per cent of the uveal melanomas expressed MMP-2 and/or MMP-9. MMP-3 expression was seen in 17 out of 26 uveal melanomas. MMP-9, previously shown to play an important part in tumour dissemination, was predominantly present in epithelioid melanomas (71.4%) or the epithelioid portion of mixed cell uveal melanomas (67%), whereas only one out of ten spindle cell melanomas showed MMP-9 expression (10%). MMP-2 and MMP-9 expression was associated with a significantly higher incidence of metastatic disease. The survival rate of patients with MMP-2-positive melanomas was 31% vs. 85% for patients with MMP-2-negative (p<0.05); for MMP-9-positive uveal melanomas the survival rate was 27% vs. 85% with MMP-9-negative uveal melanomas (p<0.04). The fact that patients suffering from TIMP-1- as well as TIMP-2-positive uveal melanomas tended to show a better survival rate (72% vs. 45% for TIMP-1; 88% vs. 37% for TIMP-2) supports the view that proteolytic enzymes are of importance in tumour spread.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
moji发布了新的文献求助10
1秒前
Imp完成签到,获得积分10
3秒前
3秒前
4秒前
量子星尘发布了新的文献求助10
4秒前
5秒前
33发布了新的文献求助30
5秒前
彦卿完成签到 ,获得积分10
6秒前
思源应助赵清持采纳,获得10
7秒前
张雯思发布了新的文献求助10
8秒前
Orange应助Shrine采纳,获得10
9秒前
10秒前
卡卡罗特发布了新的文献求助10
10秒前
cdytjt完成签到,获得积分10
12秒前
15秒前
ding应助小田心采纳,获得10
15秒前
15秒前
15秒前
16秒前
16秒前
wwl发布了新的文献求助10
17秒前
鹏程万里完成签到,获得积分10
18秒前
星辰大海应助li采纳,获得10
19秒前
chasikan发布了新的文献求助30
20秒前
cxy发布了新的文献求助10
21秒前
幸福大白发布了新的文献求助10
22秒前
大个应助贾克斯采纳,获得10
24秒前
过时的画板完成签到,获得积分10
24秒前
大气小蘑菇完成签到,获得积分10
27秒前
28秒前
小田心发布了新的文献求助10
34秒前
千跃举报求助违规成功
34秒前
whatever举报求助违规成功
34秒前
wdy111举报求助违规成功
34秒前
34秒前
tongluobing完成签到,获得积分10
35秒前
我是老大应助深情的雁露采纳,获得10
36秒前
37秒前
Singularity应助爱笑晓曼采纳,获得20
37秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989406
求助须知:如何正确求助?哪些是违规求助? 3531522
关于积分的说明 11254187
捐赠科研通 3270174
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174