Enantioselective synthesis of benzazepinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids

SPA-catalyzed iso-Pictet–Spengler reaction of C-2-linked o-aminobenzylindoles and trifluoromethyl ketones for construction of optically enriched benzazepinoindole derivatives has been realised.