体内分布
纳米载体
纳米技术
纳米医学
药代动力学
药品
药物输送
药理学
计算机科学
计算生物学
医学
纳米颗粒
材料科学
生物
生物技术
体内
作者
S. Moein Moghimi,A. Christy Hunter,Thomas L. Andresen
出处
期刊:Annual Review of Pharmacology and Toxicology
[Annual Reviews]
日期:2011-03-03
卷期号:52 (1): 481-503
被引量:493
标识
DOI:10.1146/annurev-pharmtox-010611-134623
摘要
Intravenously injected nanoparticulate drug carriers provide a wide range of unique opportunities for site-specific targeting of therapeutic agents to many areas within the vasculature and beyond. Pharmacokinetics and biodistribution of these carriers are controlled by a complex array of interrelated core and interfacial physicochemical and biological factors. Pertinent to realizing therapeutic goals, definitive maps that establish the interdependency of nanoparticle size, shape, and surface characteristics in relation to interfacial forces, biodistribution, controlled drug release, excretion, and adverse effects must be outlined. These concepts are critically evaluated and an integrated perspective is provided on the basis of the recent application of nanoscience approaches to nanocarrier design and engineering. The future of this exciting field is bright; some regulatory-approved products are already on the market and many are in late-phase clinical trials. With concomitant advances in extensive computational knowledge of the genomics and epigenomics of interindividual variations in drug responses, the boundaries toward development of personalized nanomedicines can be pushed further.
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