Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model

医学 麻醉 创伤性脑损伤 头部受伤 心脏病学 外科 精神科
作者
Tracy K. McIntosh,Robert Vink,Linda J. Noble‐Haeusslein,Iwao Yamakami,Susan Fernyak,Holly Soares,A I Faden
出处
期刊:Neuroscience [Elsevier]
卷期号:28 (1): 233-244 被引量:1113
标识
DOI:10.1016/0306-4522(89)90247-9
摘要

Experimental fluid-percussion models produce brain injury by rapidly injecting saline into the closed cranium. In the present study we characterize the physiological, histopathological and neurological responses to mechanical brain injury in the rat produced by lateral fluid-percussion injury of graded severity. Physiological experiments (n = 105) demonstrated that all levels of injury produced an acute and transient systemic hypertension and bradycardia. Acute hypertension followed by significant hypotension occurred at higher magnitudes of injury. Post-injury suppression of electroencephalographic amplitude was related to the severity of injury. An increase in slow wave (delta/theta) electroencephalographic activity with a concomitant decrease in alpha/beta electroencephalographic activity were observed only at moderate and high magnitude of injury and were correlated with a worsened neurological outcome (r = 0.84; P less than 0.05) and increased mortality (r = 0.66; P less than 0.05). Alterations in brainstem auditory-evoked potentials were also observed only at the higher levels of injury. Histopathological analysis revealed that the extent of post-injury hemorrhage, cavitation and vascular disruption (as measured by extravasation of Evans Blue dye) was greater at the higher magnitudes of injury. Neurological scoring performed over a 4-week post-injury period demonstrated that lateral fluid-percussion brain injury produces a chronic neurological deficit that is directly related to the severity of injury. Survival was also significantly reduced at the higher magnitudes of injury. These data demonstrate that the lateral model of fluid-percussion injury in the rat reproduces many of the features of head injury observed in other models and species and may therefore be a useful experimental model for the study of the pathophysiology of traumatic brain injury.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
hchen完成签到 ,获得积分10
3秒前
boom完成签到,获得积分20
7秒前
直率千山完成签到,获得积分10
7秒前
跳跃的白云完成签到 ,获得积分10
8秒前
万能图书馆应助小兰采纳,获得10
11秒前
科研通AI2S应助DARKNESS采纳,获得10
12秒前
13秒前
13秒前
YoYo发布了新的文献求助10
13秒前
小蘑菇应助热情芝麻采纳,获得10
15秒前
wuxunxun2015完成签到,获得积分10
16秒前
lzx发布了新的文献求助10
16秒前
sam给英俊雅琴的求助进行了留言
18秒前
Pony完成签到,获得积分10
18秒前
娜娜发布了新的文献求助10
19秒前
20秒前
FashionBoy应助cbf采纳,获得10
20秒前
20秒前
mengli完成签到 ,获得积分10
21秒前
健壮的百褶裙完成签到,获得积分10
21秒前
22秒前
lzx完成签到,获得积分10
23秒前
jason完成签到,获得积分10
24秒前
寸木完成签到 ,获得积分10
25秒前
jioujg发布了新的文献求助10
26秒前
ming发布了新的文献求助10
26秒前
qing完成签到,获得积分10
28秒前
光亮的世界完成签到,获得积分20
28秒前
wyy发布了新的文献求助10
29秒前
隐形曼青应助YoYo采纳,获得10
32秒前
jioujg完成签到,获得积分10
33秒前
2810527600完成签到,获得积分10
34秒前
41秒前
777y完成签到,获得积分10
43秒前
46秒前
Owen应助BlingBling的我呀采纳,获得10
47秒前
wyy完成签到,获得积分10
52秒前
含蓄的惜梦完成签到 ,获得积分10
53秒前
谭显芝完成签到,获得积分10
53秒前
56秒前
高分求助中
The Oxford Handbook of Social Cognition (Second Edition, 2024) 1050
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Chen Hansheng: China’s Last Romantic Revolutionary 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3140405
求助须知:如何正确求助?哪些是违规求助? 2791283
关于积分的说明 7798359
捐赠科研通 2447650
什么是DOI,文献DOI怎么找? 1301996
科研通“疑难数据库(出版商)”最低求助积分说明 626359
版权声明 601194