免疫系统
免疫学
抗原
生物
呼吸道
抗原呈递
T细胞
细胞
肺
淋巴细胞
抗原提呈细胞
细胞生物学
呼吸系统
医学
内科学
解剖
遗传学
出处
期刊:The European respiratory journal
[European Respiratory Society]
日期:1993-01-01
卷期号:6 (1): 120-129
被引量:124
标识
DOI:10.1183/09031936.93.06010120
摘要
A variety of cell populations present in respiratory tract tissues can express the function-associated molecules on their surface which are required for presentation of antigen to T-lymphocyte receptors. However, the potential role of individual cell populations in regulation of local T-lymphocyte-dependent immune reactions in the lung and airways depends on a variety of additional factors, including their precise localisation, migration characteristics, expression of T-cell "co-stimulatory" signals, responsiveness to inflammatory (in particular cytokine) stimuli, host immune status, and the nature of the antigen challenge. Recent evidence (reviewed below) suggests that the induction of primary immunity (viz. "sensitisation") to inhaled antigens is normally controlled by specialised populations of Dendritic Cells, which perform a surveillance role within the epithelia of the upper and lower respiratory tract; in the pre-sensitised host, a variety of other cell populations (both bone-marrow derived and mesenchymal) may participate in re-stimulation of "memory" T-lymphocytes.
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