树突棘
小RNA
翻译(生物学)
生物
神经科学
突触后电位
突触可塑性
突触
神经传递
神经系统
信使核糖核酸
细胞生物学
海马结构
受体
遗传学
基因
作者
Gerhard Schratt,Fabian Tuebing,Elizabeth A. Nigh,Christina G. Kane,Mary E. Sabatini,Michael Kiebler,Michael E. Greenberg
出处
期刊:Nature
[Springer Nature]
日期:2006-01-19
卷期号:439 (7074): 283-289
被引量:1738
摘要
MicroRNAs are small, non-coding RNAs that control the translation of target messenger RNAs, thereby regulating critical aspects of plant and animal development. In the mammalian nervous system, the spatiotemporal control of mRNA translation has an important role in synaptic development and plasticity. Although a number of microRNAs have been isolated from the mammalian brain, neither the specific microRNAs that regulate synapse function nor their target mRNAs have been identified. Here we show that a brain-specific microRNA, miR-134, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines--postsynaptic sites of excitatory synaptic transmission. This effect is mediated by miR-134 inhibition of the translation of an mRNA encoding a protein kinase, Limk1, that controls spine development. Exposure of neurons to extracellular stimuli such as brain-derived neurotrophic factor relieves miR-134 inhibition of Limk1 translation and in this way may contribute to synaptic development, maturation and/or plasticity.
科研通智能强力驱动
Strongly Powered by AbleSci AI