Nonpharmacologic treatment options are effective in reducing seizures and improving quality of life without the negative side effects associated with antiepileptic drug (AED) therapy among pediatric epilepsy patients. One such treatment, vagus nerve stimulation (VNS) therapy, appears to be particularly effective among pediatric patients with refractory seizures. Seizure severity and frequency, as well as quality of life, are improved with VNS therapy.