炎症性肠病
CXCR4型
炎症性肠病
疾病
炎症
趋化因子
化学
医学
免疫学
癌症研究
病理
作者
Lael Werner,Hanan Guzner‐Gur,Iris Dotan
出处
期刊:Theranostics
[Ivyspring International Publisher]
日期:2013-01-01
卷期号:3 (1): 40-46
被引量:89
摘要
Directional movement of cells in the human body is orchestrated via chemokines. This migration was initially identified in pathological and immunological processes but quickly extended to homeostatic cell trafficking. One such chemokine is the ubiquitous CXCL12 (initially called SDF1-α) which signals via the chemokine receptors CXCR4 and CXCR7. In the last decade CXCL12 was recognized to participate not only in embryonic development and homeostatic maintenance, but also in progression of inflammation. A role for CXCL12 and its receptors CXCR4 and CXCR7 in inflammatory bowel diseases was recently shown. The current review discusses up to date knowledge of CXCL12 in inflammation, focusing on the involvement of CXCL12 and its receptors, CXCR4 and CXCR7, in inflammatory bowel diseases.
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