肌上皮细胞
卡尔波宁
病理
免疫组织化学
细胞角蛋白
角蛋白
S100蛋白
染色
角蛋白7
粘液表皮样癌
生物
癌
医学
作者
Hala Rizkalla,Mary Toner
标识
DOI:10.1111/j.1365-2559.2007.02762.x
摘要
To investigate the use of immunohistochemistry in distinguishing necrotizing sialometaplasia (NSM) from squamous cell (SCC) and mucoepidermoid carcinoma (MEC) by (i) the identification of myoepithelial cells and (ii) cytokeratin (CK) expression.Thirteen cases with the histological changes of NSM, eight SCCs and eight MECs were examined with the following immunohistochemical markers: calponin, S100, smooth muscle actin (SMA), p63, CK7, CK5, CK6 and CAM5.2. The distribution and intensity of staining were recorded. Residual myoepithelial cells (best demonstrated by calponin and SMA) were identified at the periphery of the epithelial islands in all cases of NSM (although not in all islands), in contrast to MEC and SCC. S100 showed a similar pattern, although staining fewer cells. Moderate rather than extensive expression of CK7 may help to distinguish NSM from MEC.Identification of myoepithelial cells and CK7 expression may help to distinguish NSM from its mimics.
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