生物化学
生物
双加氧酶
荧蒽
基因
操纵子
突变体
天体生物学
菲
作者
Debebe Alemayehu,Linda Gordon,Mark M. O'Mahony,Niall O'Leary,Alan D. W. Dobson
出处
期刊:Fems Microbiology Letters
[Oxford University Press]
日期:2004-10-01
卷期号:239 (2): 285-293
被引量:28
标识
DOI:10.1016/j.femsle.2004.08.046
摘要
A novel indole dioxygenase (idoA) gene has been cloned from Pseudomonas alcaligenes PA-10, based on its ability to convert indole to indigo. The chromosomally encoded idoA gene exhibits no similarity to previously cloned naphthalene dioxygenases or to aromatic oxygenases from other species at the nucleotide level. Phylogenetic analysis indicates that the idoA gene product is most similar to an acyl-CoA dehydrogenase from Novosphingobium aromaticivorans. The enzyme encoded by the idoA gene is essential for the metabolism of fluoranthene, since a mutant in which the idoA gene has been disrupted looses the ability to degrade this compound. The idoA gene appears to be constitutively expressed in PA-10, but its expression is also subject to regulation following prior exposure to salicylate and to fluoranthene degradative intermediates.
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