Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate.

医学 射血分数 心脏病学 冲程容积 内科学 心输出量 心率 心功能曲线 舒张期 收缩末期容积 舒张末期容积 血压 血流动力学 心力衰竭
作者
Richard J. Rodeheffer,Gary Gerstenblith,Lewis C. Becker,Jerome L. Fleg,Myron L. Weisfeldt,Edward G. Lakatta
出处
期刊:Circulation [Ovid Technologies (Wolters Kluwer)]
卷期号:69 (2): 203-213 被引量:653
标识
DOI:10.1161/01.cir.69.2.203
摘要

To assess the effect of age on cardiac volumes and function in the absence of overt or occult coronary disease, we performed serial gated blood pool scans at rest and during progressive upright bicycle exercise to exhaustion in 61 participants in the Baltimore Longitudinal Study of Aging. The subjects ranged in age from 25 to 79 years and were free of cardiac disease according to their histories and results of physical, resting and stress electrocardiographic, and stress thallium scintigraphic examinations. Absolute left ventricular volumes were obtained at each workload. There were no age-related changes in cardiac output, end-diastolic or end-systolic volumes, or ejection fraction at rest. During vigorous exercise (125 W), cardiac output was not related to age (cardiac output [1/min] = 16.02 + 0.03 [age]; r = .12, p = .46). However, there was an age-related increase in end-diastolic volume (end-diastolic volume [ml] = 86.30 + 1.48 [age]; r = .47, p = .003) and stroke volume (stroke volume [ml] = 85.52 + 0.80 [age]; r = .37, p = .02), and an age-related decrease in heart rate (heart rate [beats/min] = 184.66 - 0.70 [age]; r = -.50, p = .002). The dependence of the age-related increase in stroke volume on diastolic filling was emphasized by the fact that at this high workload end-systolic volume was higher (end-systolic volume [ml] = 3.09 + 0.65 [age]; r = .45, p = .003) and ejection fraction lower (ejection fraction = 88.48 - 0.18 [age]; r = -.33, p = .04) with increasing age. These findings indicate that although aging does not limit cardiac output per se in healthy community-dwelling subjects, the hemodynamic profile accompanying exercise is altered by age and can be explained by an age-related diminution in the cardiovascular response to beta-adrenergic stimulation.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
闾丘惜萱完成签到,获得积分10
刚刚
打打应助哈哈采纳,获得10
3秒前
app完成签到 ,获得积分10
3秒前
3秒前
Akim应助yaooo采纳,获得10
3秒前
todayisirene发布了新的文献求助10
3秒前
3秒前
情怀应助奔跑的棉花采纳,获得10
4秒前
毛竹完成签到,获得积分10
5秒前
汉堡包应助xj305采纳,获得10
5秒前
酷波er应助Fisheep采纳,获得10
5秒前
5秒前
田様应助Fisheep采纳,获得10
5秒前
6秒前
shuoshuo发布了新的文献求助10
6秒前
6秒前
hahahaweiwei发布了新的文献求助10
6秒前
打打应助Catalysis123采纳,获得10
7秒前
7秒前
8秒前
英姑应助舒心的南烟采纳,获得10
8秒前
今后应助CrysLantZ采纳,获得10
8秒前
迷人的沛山完成签到 ,获得积分10
8秒前
CodeCraft应助flippedaaa采纳,获得10
8秒前
8秒前
丹东东发布了新的文献求助10
8秒前
sfsfs发布了新的文献求助30
9秒前
雪白雪糕完成签到,获得积分10
10秒前
同城代打发布了新的文献求助10
10秒前
刻苦的雪莲完成签到,获得积分20
10秒前
11秒前
华仔应助葛辉辉采纳,获得10
11秒前
煮饭吃Zz完成签到 ,获得积分10
12秒前
12秒前
14秒前
嗯哼应助安琪采纳,获得20
14秒前
14秒前
满意无极发布了新的文献求助10
16秒前
LEOhard发布了新的文献求助10
16秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 830
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3247247
求助须知:如何正确求助?哪些是违规求助? 2890639
关于积分的说明 8264046
捐赠科研通 2559077
什么是DOI,文献DOI怎么找? 1387740
科研通“疑难数据库(出版商)”最低求助积分说明 650640
邀请新用户注册赠送积分活动 627321