生物
间充质
胚胎发生
器官发生
句号(音乐)
胚胎干细胞
基因表达
内胚层
基因
微阵列分析技术
细胞生物学
基因表达调控
基因表达谱
微阵列
遗传学
分子生物学
胚胎
物理
声学
作者
Young Kyu Park,Jeffrey L. Franklin,Stephen H. Settle,Shawn Levy,Eun‐Kyung Chung,Loice H. Jeyakumar,Yu Shyr,M. Kay Washington,Robert H. Whitehead,Bruce J. Aronow,Robert J. Coffey
出处
期刊:Genesis
[Wiley]
日期:2005-01-01
卷期号:41 (1): 1-12
被引量:21
摘要
During late embryogenesis, the mouse colon develops from a pseudostratified, undifferentiated endoderm to a single-layered columnar epithelium with accompanying mesenchymal maturation. To identify regulatory genetic programs underlying these morphological changes, we profiled gene expression of the developing mouse colon by microarray from embryonic day (E)13.5 to E18.5. Unbiased cluster analysis of 13,484 cDNA elements revealed two distinct groups of genes whose expression changes reflect the dynamic morphological events of the epithelium and mesenchyme during this period. Additional analyses revealed two subsets of genes whose expression is either upregulated or downregulated over the same developmental period. Of those genes whose expression increases from E13.5 to E18.5 (n = 158), known functions include acquisition and/or maintenance of colonic differentiation. Genes whose transcription is downregulated over this period (n = 49) have demonstrated roles in nuclear organization, transcriptional regulation, and cell proliferation. These results provide the basis for a molecular portrait of colonic development during late embryogenesis and should be a valuable resource for investigators interested in colonic development and neoplasia, as well as comparative organogenesis. genesis 41:1–12, 2005. © 2005 Wiley-Liss, Inc.
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