Rationally engineered variants of S-adenosylmethionine (SAM) synthase: reduced product inhibition and synthesis of artificial cofactor homologues

Rational redesign of bacterialS-adenosylmethionine-synthase by 3D-modelling and docking led to variants that allow synthesis of methylation cofactor SAM (AdoMet) without product inhibition, and of higher alkyl homologues.