High coffee consumption, brain volume and risk of dementia and stroke

痴呆 冲程(发动机) 大脑大小 医学 消费(社会学) 内科学 心理学 神经科学 磁共振成像 疾病 工程类 社会科学 机械工程 放射科 社会学
作者
Kitty Pham,Anwar Mulugeta,Ang Zhou,John T. O’Brien,David J. Llewellyn,Elina Hyppönen
出处
期刊:Nutritional Neuroscience [Informa]
卷期号:25 (10): 2111-2122 被引量:26
标识
DOI:10.1080/1028415x.2021.1945858
摘要

Background Coffee is a highly popular beverage worldwide, containing caffeine which is a central nervous system stimulant.Objectives We examined whether habitual coffee consumption is associated with differences in brain volumes or the odds of dementia or stroke.Methods We conducted prospective analyses of habitual coffee consumption on 398,646 UK Biobank participants (age 37–73 years), including 17,702 participants with MRI information. We examined the associations with brain volume using covariate adjusted linear regression, and with odds of dementia (4,333 incident cases) and stroke (6,181 incident cases) using logistic regression.Results There were inverse linear associations between habitual coffee consumption and total brain (fully adjusted β per cup −1.42, 95% CI −1.89, −0.94), grey matter (β −0.91, 95% CI −1.20, −0.62), white matter (β −0.51, 95% CI −0.83, −0.19) and hippocampal volumes (β −0.01, 95% CI −0.02, −0.003), but no evidence to support an association with white matter hyperintensity (WMH) volume (β −0.01, 95% CI −0.07, 0.05). The association between coffee consumption and dementia was non-linear (Pnon-linearity = 0.0001), with evidence for higher odds for non-coffee and decaffeinated coffee drinkers and those drinking >6 cups/day, compared to light coffee drinkers. After full covariate adjustment, consumption of >6 cups/day was associated with 53% higher odds of dementia compared to consumption of 1–2 cups/day (fully adjusted OR 1.53, 95% CI 1.28, 1.83), with less evidence for an association with stroke (OR 1.17, 95% CI 1.00, 1.37, p = 0.055).Conclusion High coffee consumption was associated with smaller total brain volumes and increased odds of dementia.
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