再生(生物学)
骨骼肌
脂肪生成
生物
祖细胞
细胞生物学
肌发生
平衡
浪费的
干细胞
人口
细胞命运测定
神经科学
解剖
间充质干细胞
内分泌学
遗传学
医学
转录因子
基因
环境卫生
作者
Giulio Giuliani,Marco Rosina,Alessio Reggio
出处
期刊:FEBS Journal
[Wiley]
日期:2021-07-06
卷期号:289 (21): 6484-6517
被引量:59
摘要
The characterization of fibro/adipogenic progenitor cells (FAPs) in the skeletal muscle has contributed to modify the monocentric view of muscle regeneration beyond muscle satellite cells (MuSCs). Now, we are aware that each population of the muscle niche plays a critical role in modulating homeostasis and regeneration. In the healthy muscle, FAPs contribute to maintain tissue homeostasis and assist MuSCs to cope with limited insults. Here, FAPs sense and integrate niche signals that keep in check their differentiation potential. The disruption of these niche cues leads to FAP differentiation into adipocytes and fibroblasts, both detrimental hallmarks of a large variety of muscle wasting diseases. FAP biology is still in its infancy, and current efforts are focused on the understanding of the molecular circuits governing their double-edged behavior. The present review offers a detailed overview of the pathways and metabolic routes that can be modulated to halt and redirect their fibro/adipogenic potential while favoring their supportive role in muscle regeneration. Finally, we discuss on how single-cell technologies have contributed to resolve FAP transitional states with distinctive roles in muscle regeneration and myopathies.
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