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S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants

脑室出血 医学 磁共振成像 胎龄 放射科 怀孕 遗传学 生物
作者
Giorgia Gasparroni,Alessandro Graziosi,Iliana Bersani,Massimo Caulo,Moataza Bashir,Hanna Aboulgar,Hala Mufeed,Iman Iskander,Maria Katarzyna Borszewska-Kornacka,Darek Gruzfeld,Andrea Dotta,Immacolata Savarese,Natalia Chukhlantseva,Lucia Gabriella Tina,Francesco Nigro,Giovanni Li Volti,Fabio Galvano,Caterina Di Battista,Ebe D’Adamo,Adele Primavera,Giuseppe Lapergola,Mariangela Conte,Rita Salomone,Marika Perrotta,Daniele Panichi,Gabriella Levantini,Milena Catenaro,Chiara Strozzi,Antonio Maconi,Giacomo Centini,Francesco Chiarelli,F. D’Antonio,Antonio W. D. Gavilanes,Diego Gazzolo
出处
期刊:Clinical Chemistry and Laboratory Medicine [De Gruyter]
卷期号:59 (9): 1527-1534 被引量:5
标识
DOI:10.1515/cclm-2021-0278
摘要

Abstract Objectives The early detection of preterm infants (PI) at risk for intraventricular hemorrhage (IVH) and neurological sequelae still constitutes an unsolved issue. We aimed at validating the role of S100B protein in the early diagnosis and prognosis of IVH in PI by means of cerebral ultrasound (CUS) and magnetic resonance imaging (MRI) today considered standard of care procedures. Methods We conducted an observational case-control study in 216 PI of whom 36 with IVH and 180 controls. Standard clinical, laboratory, radiological monitoring procedures and S100B urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Cerebral MRI was performed at 40–42 weeks of corrected gestational age. Results Elevated (p<0.001, for all) S100B levels were observed in the IVH group at all monitoring time-point particularly at first void when standard monitoring procedures were still silent or unavailable. S100B measured at first void correlated (p<0.001) with the grade of hemorrhage by means of CUS and with the site and extension of neurological lesion (p<0.001, for all) as assessed by MRI. Conclusions The present results showing a correlation among S100B and CUS and MRI offer additional support to the inclusion of the protein in clinical daily management of cases at risk for IVH and adverse neurological outcome. The findings open the way to further investigations in PI aimed at validating new neurobiomarkers by means of S100B.
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