内质网
未折叠蛋白反应
细胞生物学
信号转导
蛋白质折叠
机制(生物学)
细胞器
平衡
化学
钙信号传导
生物
认识论
哲学
作者
Shizhen Zhao,Xinping Li,Ping Lu,Xiaotian Li,Ming-Fei Sun,Honggang Wang
标识
DOI:10.3389/fcell.2021.646723
摘要
Endoplasmic reticulum (ER) is a kind of organelle with multiple functions including protein synthesis, modification and folding, calcium storage, and lipid synthesis. Under stress conditions, ER homeostasis is disrupted, which is defined as ER stress (ERS). The accumulation of unfolded proteins in the ER triggers a stable signaling network named unfolded protein response (UPR). Hydrogen sulfide is an important signal molecule regulating various physiological and pathological processes. Recent studies have shown that H 2 S plays an important role in many diseases by affecting ERS, but its mechanism, especially the signaling pathways, is not fully understood. Therefore, in this review, we summarize the recent studies about the signaling pathways involved in the effects of H 2 S on ERS in diseases to provide theoretical reference for the related in-depth researches.
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