已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Antioxidant property, haematinic and biosafety effect of Ipomoea batatas lam. leaf extract in animal model

抗氧化剂 DPPH 苯肼 生育酚 抗坏血酸 甘薯 医学 化学 传统医学 动物科学 生物 维生素E 食品科学 生物化学 植物 药物化学
作者
Benjamin Ogunma Gabriel,MacDonald Idu
出处
期刊:Beni-Suef University Journal of Basic and Applied Sciences [Springer Nature]
卷期号:10 (1) 被引量:4
标识
DOI:10.1186/s43088-021-00161-4
摘要

Abstract Background Plant medicine was dated back for decades and has immensely contributed to the health care system in several countries. This present study evaluated in vitro antioxidant, anti-anaemic and biosafety properties of n-hexane leaf extract of Ipomoea batatas L. in an animal model. The antioxidant property of the extract was expressed by 1, 1-diphenyl-1-picrylhydrazyl (DPPH) with an appropriate method. The extract was orally administered at graded doses (125, 250 and 500 mg/kg body weight) to determine its effect on 40 mg/kg phenylhydrazine hydrochloride-induced anaemia in rats at days 1, 7 and 14 using a standard protocol. Acute and subacute toxicological evaluations were based on initial behaviour, mortality and histological examination of the organs. Results The antioxidant study of the extract showed 60.14% in the presence of DPPH and ascorbic acid. The haematological parameters ( RBC, HGB, HCT, MCV, MCH and MCHC) significantly increased at p value < 0.05 in the treated groups compared with control groups. Specifically, there is a significant increase in the treatment groups, namely red blood cells (5.93, 6.78, 6.75), haematocrit (40.75, 44.05, 44.63) and haemoglobin (13.35, 14.70, 14.73), when compared with untreated control. Also, the results of the myeloid/erythroid ratio of the treated groups (20: 40, 21.7: 43.4 ratio) and (23. 3: 46.6 ratio) are compared with (15.0: 25.0 ratio) of 40 mg/kg phenylhydrazine and 25: 50 normal control of the bone marrow at day 14. No acute behavioural change or mortality was observed. Histological analysis exhibited normal physiological state of the visceral organs. Conclusions These findings support the folklore use of Ipomoea batatas L. leaf extract to reduce oxidative stress, treat anaemia and exhibit its safety at the highest doses of 500 mg/kg body weight.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
柒啊柒la发布了新的文献求助10
刚刚
1秒前
2秒前
5秒前
百无禁忌发布了新的文献求助10
7秒前
9秒前
积极的香菇完成签到 ,获得积分10
10秒前
充电宝应助科研喜剧人采纳,获得10
11秒前
现代的邑完成签到,获得积分10
13秒前
董绮敏完成签到 ,获得积分10
15秒前
情怀应助明明采纳,获得10
15秒前
15秒前
害羞便当完成签到 ,获得积分10
16秒前
科研通AI2S应助曾经的又莲采纳,获得10
16秒前
18秒前
18秒前
弄巷发布了新的文献求助10
21秒前
李爱国应助1234567890采纳,获得10
21秒前
传奇3应助热情秋白采纳,获得10
22秒前
23秒前
狂野的元容完成签到,获得积分10
24秒前
科研通AI2S应助成阳采纳,获得10
24秒前
24秒前
24秒前
shizaibide1314完成签到,获得积分10
26秒前
Colin发布了新的文献求助10
27秒前
科目三应助秉烛游采纳,获得10
28秒前
31秒前
领导范儿应助浅忆采纳,获得10
32秒前
33秒前
搜集达人应助柒啊柒la采纳,获得10
39秒前
40秒前
xiaodengdream发布了新的文献求助10
41秒前
威武的晓丝完成签到,获得积分10
43秒前
wangy完成签到 ,获得积分10
44秒前
嗯哼给luluki的求助进行了留言
45秒前
50秒前
CipherSage应助CC采纳,获得10
51秒前
51秒前
叶问夏完成签到 ,获得积分10
52秒前
高分求助中
Medicina di laboratorio. Logica e patologia clinica 600
FDA-2: Frenchay Dysarthria Assessment 500
Sarcolestes leedsi Lydekker, an ankylosaurian dinosaur from the Middle Jurassic of England 500
《关于整治突出dupin问题的实施意见》(厅字〔2019〕52号) 500
Language injustice and social equity in EMI policies in China 500
mTOR signalling in RPGR-associated Retinitis Pigmentosa 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3215481
求助须知:如何正确求助?哪些是违规求助? 2864101
关于积分的说明 8141320
捐赠科研通 2530314
什么是DOI,文献DOI怎么找? 1364593
科研通“疑难数据库(出版商)”最低求助积分说明 644196
邀请新用户注册赠送积分活动 616776