Microemulsified Gel Formulations for Topical Delivery of Clotrimazole: Structural and In Vitro Evaluation

克霉唑 肺表面活性物质 微乳液 化学 傅里叶变换红外光谱 化学工程 生物相容性材料 羟丙基纤维素 药物输送 色谱法 材料科学 纳米技术 生物医学工程 有机化学 工程类 聚合物 抗真菌 医学 生物化学 皮肤病科
作者
Muhammad Yasir Siddique,Muhammad Faizan Nazar,Marryam Mahmood,Muhammad Atif Saleem,Norah Alwadai,Amani Saleh Almuslem,Fwzah H. Alshammari,Sajjad Haider,Muhammad Saeed Akhtar,Syed Zajif Hussain,Nasia Safdar,Muhammad Akhlaq
出处
期刊:Langmuir [American Chemical Society]
卷期号:37 (46): 13767-13777 被引量:16
标识
DOI:10.1021/acs.langmuir.1c02590
摘要

Microemulsified gels (μEGs) with fascinating functions have become indispensable as topical drug delivery systems due to their structural flexibility, high stability, and facile manufacturing process. Topical administration is an attractive alternative to traditional methods because of advantages such as noninvasive administration, bypassing first-pass metabolism, and improving patient compliance. In this article, we report on the new formulations of microemulsion-based gels suitable for topical pharmaceutical applications using biocompatible and ecological ingredients. For this, two biocompatible μE formulations comprising clove oil/Brij-35/water/ethanol (formulation A) and clove oil/Brij-35/water/1-propanol (formulation B) were developed to encapsulate and improve the load of an antimycotic drug, Clotrimazole (CTZ), and further gelatinized to control the release of CTZ through skin barriers. By delimiting the pseudo-ternary phase diagram, optimum μE formulations with clove oil (∼15%) and Brij-35 (∼30%) were developed, keeping constant surfactant/co-surfactant ratio (1:1), to upheld 2.0 wt % CTZ. The as-developed formulations were further converted into smart gels by adding 2.0 wt % carboxymethyl cellulose (CMC) as a cross-linker to adhere to the controlled release of CTZ through complex skin barriers. Electron micrographs show a fine, monodispersed collection of CTZ-μE nanodroplets (∼60 nm), which did not coalesce even after gelation, forming spherical CTZ-μEG (∼90 nm). However, the maturity of CTZ nanodroplets observed by dynamic light scattering suggests the affinity of CTZ for the nonpolar microenvironment, which was further supported by the peak-to-peak correlation of Fourier transform infrared (FTIR) analysis and fluorescence measurement. In addition, HPLC analysis showed that the in vitro permeation release of CTZ-μEG from rabbit skin in the ethanolic phosphate buffer (pH = 7.4) was significantly increased by >98% within 6.0 h. This indicates the sustained release of CTZ in μEBG and the improvement in transdermal therapeutic efficacy of CTZ over its traditional topical formulations.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
听你发布了新的文献求助10
刚刚
1秒前
1秒前
gchen001完成签到,获得积分10
1秒前
脑洞疼应助z945采纳,获得10
1秒前
3秒前
Tian_lanlan发布了新的文献求助10
3秒前
4秒前
Ava应助xy采纳,获得10
5秒前
Coco完成签到,获得积分10
5秒前
肖ks完成签到,获得积分10
5秒前
852应助执着新蕾采纳,获得10
6秒前
careS完成签到,获得积分10
6秒前
leslie发布了新的文献求助10
7秒前
情怀应助豆子采纳,获得10
8秒前
欣喜念桃发布了新的文献求助10
8秒前
微笑访枫应助灰灰采纳,获得10
10秒前
wanci应助chongchong采纳,获得10
10秒前
SciGPT应助KevinDante采纳,获得30
10秒前
Owen应助chenli900108采纳,获得10
11秒前
11秒前
baozi发布了新的文献求助10
12秒前
goldNAN发布了新的文献求助10
13秒前
zommen发布了新的文献求助200
13秒前
lin发布了新的文献求助10
13秒前
量子星尘发布了新的文献求助10
13秒前
CodeCraft应助自然的书易采纳,获得10
14秒前
李爱国应助科研通管家采纳,获得10
14秒前
14秒前
arabidopsis应助科研通管家采纳,获得10
14秒前
8R60d8应助科研通管家采纳,获得30
14秒前
meteor应助科研通管家采纳,获得10
14秒前
meteor应助科研通管家采纳,获得10
14秒前
orixero应助科研通管家采纳,获得10
14秒前
爆米花应助科研通管家采纳,获得10
15秒前
在水一方应助科研通管家采纳,获得10
15秒前
科研通AI2S应助科研通管家采纳,获得10
15秒前
15秒前
15秒前
15秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971277
求助须知:如何正确求助?哪些是违规求助? 3516009
关于积分的说明 11180382
捐赠科研通 3251075
什么是DOI,文献DOI怎么找? 1795664
邀请新用户注册赠送积分活动 875988
科研通“疑难数据库(出版商)”最低求助积分说明 805209