Abstract 10061: Association of Frailty with In-Hospital and Long-Term Outcomes Among St-Elevation Myocardial Infarction Patients Receiving Primary PCI

HomeCirculationAbstract 10061: Association of Frailty with In-Hospital and Long-Term Outcomes Among St-Elevation Myocardial Infarction Patients Receiving Primary PCI Free AccessAbstractAboutSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractAcute Coronary SyndromesSession Title: Stable Ischemic Heart Disease and Acute Coronary SyndromesAbstract 10061: Association of Frailty with In-Hospital and Long-Term Outcomes Among St-Elevation Myocardial Infarction Patients Receiving Primary PCI Farshad Hosseini, Ian Pitcher, Mehima Kang, Martha MacKay, Joel Singer, Terry Lee, Kenneth Madden, John A CAIRNS, Graham C Wong and Christopher Fordyce Farshad HosseiniFarshad Hosseini Medicine, Univ of British Columbia, Vancouver, Canada Search for more papers by this author , Ian PitcherIan Pitcher Cardiology, Univ of British Columbia, Vancouver, Canada Search for more papers by this author , Mehima KangMehima Kang Faculty of Medicine, Univ of British Columbia, Vancouver, Canada Search for more papers by this author , Martha MacKayMartha MacKay ST PAULS HOSPITAL, Vancouver, Canada Search for more papers by this author , Joel SingerJoel Singer UNIVERSITY OF BRITISH COLUMBIA, Vancouver, Canada Search for more papers by this author , Terry LeeTerry Lee vancouver, Canada Search for more papers by this author , Kenneth MaddenKenneth Madden Geriatric Medicine, Univ of British Columbia, Vancouver, Canada Search for more papers by this author , John A CAIRNSJohn A CAIRNS UNIVERSITY BRITISH COLUMBIA, Vancouver, Canada Search for more papers by this author , Graham C WongGraham C Wong UNIVERSITY OF BRITISH COLUMBIA, Vancouver, TX Search for more papers by this author and Christopher FordyceChristopher Fordyce Univ of British Columbia, Vancouver, Canada Search for more papers by this author Originally published8 Nov 2021https://doi.org/10.1161/circ.144.suppl_1.10061Circulation. 2021;144:A10061AbstractIntroduction: The impact of frailty on outcomes in a contemporary ST-segment-elevation myocardial infarction (STEMI) population is unclear. This study hypothesized that frail STEMI patients undergoing primary percutaneous coronary intervention (pPCI) have worse in-hospital and 1-year outcomes compared to non-frail STEMI patients.Methods: We retrospectively identified 600 STEMI patients who had received pPCI (2013 - 2016). A frailty index (FI) was determined using the health deficit accumulation model (Table 1). Frail patients were defined as those with a FI > 0.25. The composite outcome comprised in-hospital heart failure, cardiogenic shock, re-infarction, major bleeding, stroke and all-cause mortality. A multivariable model adjusting for age and sex was performed.Results: Among 600 STEMI patients receiving pPCI, 67 (11.2%) were classified as frail. Compared to non-frail patients, frail patients were older (mean 80.3 vs. 75.8 years, p < 0.001) and had a higher comorbidity burden. After adjustment, baseline frailty was independently associated with delayed reperfusion time, in-hospital all-cause mortality, and higher incidence of the composite outcome (Figure 1). Frailty was also associated with increased 1-year all-cause mortality and cardiovascular rehospitalization.Conclusions: Among STEMI patients receiving pPCI, 1 in 10 were frail. Frailty was associated with increased rate of the primary in-hospital composite adverse outcome, delayed reperfusion time and worse long-term outcomes. Efforts to routinely identify frail STEMI patients and to implement best practices to reduce the risk of adverse events in this vulnerable population are warranted.Download figureDownload figureFootnotesAuthor Disclosures: For author disclosure information, please visit the AHA Scientific Sessions 2021 Online Program Planner and search for the abstract title. eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails November 16, 2021Vol 144, Issue Suppl_1 Advertisement Article Information Metrics © 2021 by American Heart Association, Inc.https://doi.org/10.1161/circ.144.suppl_1.10061 Originally publishedNovember 8, 2021 KeywordsAcute coronary syndromesGeriatricsOlder populationOutcomesSTEMI Advertisement