肿瘤微环境
结直肠癌
基质
转移
生物
血管生成
癌症
细胞外基质
癌症研究
肿瘤进展
核梭杆菌
肠道菌群
免疫学
病理
免疫系统
医学
细胞生物学
免疫组织化学
细菌
遗传学
牙龈卟啉单胞菌
作者
Toru Miyake,Masaji Tani
出处
期刊:Gan to kagaku ryoho. Cancer & chemotherapy
日期:2021-09-01
卷期号:48 (9): 1100-1102
摘要
Gut microbes are one of the essential components of the tumor microenvironment, the same as interstitial stroma, angiogenesis, and immunity. With the advancement of technology, it has become possible to analyze various bacterial flora without culturing microbiomes comprehensively. There are a massive amount of gut microbes in the large intestine compared with other organs. It has been reported that some species of gut microbes, such as Fusobacterium nucleatum, are involved in the progression and metastasis of colorectal cancer and resistance to chemotherapy, with multiple mechanisms. The interstitial stroma composed of an extracellular matrix is also one of the crucial components of the tumor microenvironment involved in cancer progression and metastasis. It has been reported that fibrosis in the invasive front of the primary tumor and metastatic lymph nodes is a poor prognostic factor in colorectal cancer. Gut microbes affect not only cancer cells but also various surrounding factors such as fibrosis and angiogenesis. Gut microbes produced many kinds of enzymes, including protease, elastase, and collagenase, which degrade the surrounding extracellular matrix and secreted cytokines to induce inflammation and remodel a cancer-specific environment. It is important to consider the cancer microenvironment, including gut microbes and interstitial stroma, for treating colorectal cancer.
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