生物正交化学
环加成
钌
化学
叠氮化物
组合化学
催化作用
点击化学
有机化学
作者
Alejandro Gutiérrez‐González,Paolo Destito,José R. Couceiro,Cibran Pérez‐González,Fernándo López,José L. Mascareñas
标识
DOI:10.1002/anie.202103645
摘要
Tailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide-thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can also be applied for the selective modification of biopolymers, such as DNA or peptides. Importantly, this ruthenium-based technology and the standard copper-catalyzed azide-alkyne cycloaddition (CuAAC) proved to be compatible and mutually orthogonal.
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