The association between triglyceride-glucose index and major adverse cardiovascular events in patients with acute coronary syndrome – dose–response meta-analysis

狼牙棒 医学 内科学 急性冠脉综合征 心肌梗塞 荟萃分析 心脏病学 观察研究 心绞痛 经皮冠状动脉介入治疗
作者
Mohammad Rizki Akbar,Raymond Pranata,Arief Wibowo,Irvan Irvan,Teddy Arnold Sihite,Januar Wibawa Martha
出处
期刊:Nutrition Metabolism and Cardiovascular Diseases [Elsevier BV]
卷期号:31 (11): 3024-3030 被引量:33
标识
DOI:10.1016/j.numecd.2021.08.026
摘要

Triglyceride-Glucose (TyG) index is an accurate biomarker of insulin resistance, which is potentially associated with adverse cardiovascular events. We aimed to assess the dose-response relationship between Triglyceride-Glucose (TyG) Index and Major Adverse Cardiovascular Events (MACE) in patients with Acute Coronary Syndrome (ACS).A systematic literature search was performed using PubMed, Scopus, and Embase for records published from the inception up until 7 February 2021. Studies that fulfilled all of these criteria were included: 1) prospective or retrospective observational studies reporting patients with ACS and 2) assessing the impact of TyG index on MACE with at least three quantitative classifications. The outcome of interest is MACE across the TyG index intervals. MACE was a composite of all-cause mortality, myocardial infarction, unstable angina pectoris, target vessel revascularization, cerebrovascular accidents, and heart failure. The effect estimates were reported as relative risks (RRs). There are 13,684 subjects from 4 studies included in this meta-analysis. This meta-analysis showed that the highest category of TyG index was associated with twofold MACE (RR 2.09 [1.59, 2.76], p < 0.001; I2: 68.4%, p = 0.02) compared to the lowest category in patients with ACS. Dose-response meta-analysis showed that the relationship between TyG index and MACE was non-linear (p < 0.001), with statistical significance reached around TyG index 8.9 and increased non-linearly. The dose-response curve became significantly steeper after TyG index of 9.1-9.2.TyG index was associated with MACE in patients with ACS in a non-linear fashion.CRD42021235765.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
无花果应助王星星采纳,获得10
4秒前
superfatcat完成签到,获得积分10
4秒前
苏雅霏完成签到 ,获得积分10
5秒前
EED发布了新的文献求助10
6秒前
7秒前
7秒前
cindywu发布了新的文献求助10
9秒前
科研通AI2S应助Huang_being采纳,获得10
9秒前
9秒前
10秒前
量子星尘发布了新的文献求助10
10秒前
HCB1发布了新的文献求助10
11秒前
11秒前
ShuXU完成签到,获得积分10
13秒前
13秒前
Pom完成签到,获得积分10
13秒前
gujiguji发布了新的文献求助10
15秒前
科研通AI2S应助HCB1采纳,获得10
15秒前
HOME发布了新的文献求助30
16秒前
阿俊发布了新的文献求助10
16秒前
18秒前
Richard发布了新的文献求助10
18秒前
FashionBoy应助sanyecai采纳,获得10
21秒前
21秒前
22秒前
科目三应助gujiguji采纳,获得10
22秒前
advance发布了新的文献求助10
24秒前
25秒前
25秒前
小二郎应助科研通管家采纳,获得10
25秒前
在水一方应助科研通管家采纳,获得10
25秒前
丘比特应助科研通管家采纳,获得10
25秒前
朱建军应助科研通管家采纳,获得30
26秒前
李健应助科研通管家采纳,获得10
26秒前
科目三应助anan采纳,获得30
26秒前
所所应助科研通管家采纳,获得10
26秒前
酷波er应助科研通管家采纳,获得10
26秒前
英姑应助科研通管家采纳,获得10
26秒前
慕青应助科研通管家采纳,获得10
26秒前
大个应助科研通管家采纳,获得30
26秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988920
求助须知:如何正确求助?哪些是违规求助? 3531290
关于积分的说明 11253247
捐赠科研通 3269903
什么是DOI,文献DOI怎么找? 1804830
邀请新用户注册赠送积分活动 882027
科研通“疑难数据库(出版商)”最低求助积分说明 809052