Risk assessment of antibiotic resistance genes in the drinking water system

整合子 抗生素 抗生素耐药性 风险评估 细菌 铜绿假单胞菌 生物 污染 四环素 16S核糖体RNA 毒理 环境化学 微生物学 化学 生态学 遗传学 计算机科学 计算机安全
作者
Yaru Hu,Lei Jiang,Xiaoyan Sun,Jin-Hui Wu,Lei Ma,Yanbo Zhou,Kuangfei Lin,Yi Luo,Changzheng Cui
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:800: 149650-149650 被引量:59
标识
DOI:10.1016/j.scitotenv.2021.149650
摘要

Antibiotic resistance genes (ARGs) are extensively detected in various environmental media, whose risk assessment in the drinking water systems has not been comprehensive. This study established a new risk assessment of ARGs in the drinking water systems, considering the chlorine-resistance ability, transferability, and ARGs harboring potential of pathogens. The risk of ARGs in a typical drinking water reservoir was also evaluated based on the detection of ARGs and antibiotic-resistant bacteria (ARB). Fourteen ARGs were detected with a relative concentration range of 10-4-10-3 (ARGs/16S rRNA gene). Five isolated ARB were identified as human opportunistic pathogens, one of which (Pseudomonas aeruginosa HLS-6, CCTCC AB 2017269) is resistant to hundreds of milligrams per liter levels of antibiotics and low-level chlorine. This result indicated that ARB tolerant to high-levels of antibiotics could be isolated from environments containing trace levels of antibiotics. Moreover, complete genome sequencing confirmed the inclusion of ARGs (sul1, aadA2) on the class I integron in HLS-6, indicating that the risk of ARGs in this drinking water reservoir could be classified as resistance risk ranking in drinking water system 1 (R3DW 1). The risk assessment of ARGs in this study provides a clear understanding of ARG risk in drinking water systems. The results reveal that the ARGs and ARB contamination of drinking water reservoirs pose significant challenges for drinking water treatment efficiency and affect drinking water safety.
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