膨胀压力
干重
化学
新月形茎杆菌
生物量(生态学)
生物物理学
生物
细胞
生物化学
生态学
植物
细胞周期
作者
Enno R. Oldewurtel,Yuki Kitahara,Sven van Teeffelen
标识
DOI:10.1073/pnas.2021416118
摘要
Significance Intracellular biomass density is an important variable for cellular physiology. It defines the crowded state of the cytoplasm and thus influences macromolecular interactions and transport. To control density during growth, bacteria must expand their cell volumes in synchrony with biomass. The regulation of volume growth and biomass density remain fundamentally not understood—in bacteria or any other organism. Using advanced microscopy, we demonstrate that cells control dry-mass density indirectly through two independent processes. First, cells expand surface area, rather than volume, in proportion with biomass growth. Second, cell width is controlled independently, with an important influence of turgor pressure. Our findings overturn a long-standing paradigm of mass-density constancy in bacteria and reveal fundamental determinants of dry-mass density and shape.
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