Pilot-phase PET/CT study targeting integrin αvβ6 in pancreatic cancer patients using the cystine-knot peptide–based 18F-FP-R01-MG-F2

医学 胰腺癌 核医学 整合素 癌症 癌症研究 内科学 化学 生物化学 受体
作者
Ryusuke Nakamoto,Valentina Ferri,Heying Duan,Negin Hatami,Mahima Goel,Jarrett Rosenberg,Richard H. Kimura,Mirwais Wardak,Tom Haywood,Rowaid Kellow,Bin Shen,Walter G. Park,Andrei Iagaru,Sanjiv S. Gambhir
出处
期刊:European Journal of Nuclear Medicine and Molecular Imaging [Springer Science+Business Media]
卷期号:50 (1): 184-193 被引量:14
标识
DOI:10.1007/s00259-021-05595-7
摘要

A novel cystine-knot peptide-based PET radiopharmaceutical, 18F-FP-R01-MG-F2 (knottin), was developed to selectively bind to human integrin αvβ6 which is overexpressed in pancreatic cancer. The purpose of this study is to evaluate the safety, biodistribution, dosimetry, and lesion uptake of 18F-FP-R01-MG-F2 in patients with pancreatic cancer.Fifteen patients (6 men, 9 women) with histologically confirmed pancreatic cancer were prospectively enrolled and underwent knottin PET/CT between March 2017 and February 2021 (ClinicalTrials.gov Identifier NCT02683824). Vital signs and laboratory results were collected before and after the imaging scans. Maximum standardized uptake values (SUVmax) and mean SUV (SUVmean) were measured in 24 normal tissues and pancreatic cancer lesions for each patient. From the biodistribution data, the organ doses and whole-body effective dose were calculated using OLINDA/EXM software.There were no significant changes in vital signs or laboratory values that qualified as adverse events or serious adverse events. At 1 h post-injection, areas of high 18F-FP-R01-MG-F2 uptake included the pituitary gland, stomach, duodenum, kidneys, and bladder (average SUVmean: 9.7-14.5). Intermediate uptake was found in the normal pancreas (average SUVmean: 4.5). Mild uptake was found in the lungs and liver (average SUVmean < 1.0). The effective dose was calculated to be 2.538 × 10-2 mSv/MBq. Knottin PET/CT detected all known pancreatic tumors in the 15 patients, although it did not detect small peri-pancreatic lymph nodes of less than 1 cm in short diameter in two of three patients who had lymph node metastases at surgery. Knottin PET/CT detected distant metastases in the lungs (n = 5), liver (n = 4), and peritoneum (n = 2), confirmed by biopsy and/or contrast-enhanced CT.18F-FP-R01-MG-F2 is a safe PET radiopharmaceutical with an effective dose comparable to other diagnostic agents. Evaluation of the primary pancreatic cancer and distant metastases with 18F-FP-R01-MG-F2 PET is feasible, but larger studies are required to define the role of this approach.NCT02683824.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
HHHAN发布了新的文献求助10
2秒前
威武的沂完成签到,获得积分10
7秒前
9秒前
10秒前
12秒前
笨笨青筠完成签到 ,获得积分10
15秒前
mengmenglv完成签到 ,获得积分0
15秒前
Tonald Yang完成签到 ,获得积分20
18秒前
19秒前
落后的怀梦完成签到 ,获得积分10
20秒前
陈坤完成签到,获得积分10
22秒前
量子星尘发布了新的文献求助10
24秒前
斯文败类应助zgx采纳,获得10
25秒前
默默完成签到 ,获得积分10
25秒前
KY Mr.WANG完成签到,获得积分10
25秒前
39秒前
guoxingliu完成签到,获得积分10
43秒前
51秒前
阳佟水蓉完成签到,获得积分10
52秒前
gdgd完成签到,获得积分10
55秒前
量子星尘发布了新的文献求助10
57秒前
叮叮当当完成签到,获得积分10
59秒前
1分钟前
1分钟前
电致阿光完成签到,获得积分10
1分钟前
ccc完成签到 ,获得积分10
1分钟前
1分钟前
zgx发布了新的文献求助10
1分钟前
i2stay完成签到,获得积分10
1分钟前
馒头完成签到,获得积分10
1分钟前
MS903完成签到,获得积分10
1分钟前
CJW完成签到 ,获得积分10
1分钟前
韧迹完成签到 ,获得积分0
1分钟前
mmd完成签到 ,获得积分10
1分钟前
七一安完成签到 ,获得积分10
1分钟前
浪麻麻完成签到 ,获得积分10
1分钟前
包容的剑完成签到 ,获得积分10
1分钟前
等待的大炮完成签到,获得积分10
1分钟前
注水萝卜完成签到 ,获得积分10
1分钟前
Chem34完成签到,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038039
求助须知:如何正确求助?哪些是违规求助? 3575756
关于积分的说明 11373782
捐赠科研通 3305574
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022