Organocatalytic Decarboxylation and Dual C(sp3)−H Bond Functionalization Toward Facile Access to Divergent 2,6‐Diarylpyridines

Abstract An effective organocatalytic protocol toward the assembly of symmetrical and unsymmetrical 2,6‐diarylpyridines is demonstrated. The reaction proceeds through organocatalytic decarboxylation of amino acid and dual C(sp 3 )−H bond oxidation of carbonyl compounds. Catalyst screening revealed that explicit choice of L‐proline could lead the formation of product with maximum yield and selectivity. The developed process appears with operational simplicity and is consistent with broad range of functional groups.