免疫系统
癌症免疫疗法
免疫疗法
癌症研究
癌症
生物
适体
癌细胞
dna疫苗
免疫学
免疫
分子生物学
遗传学
作者
Bo Liu,Yu Yang,Yu Chao,Zhisheng Xiao,Jialu Xu,Chunjie Wang,Ziliang Dong,Linqian Hou,Qiaofeng Li,Zhuang Liu
出处
期刊:Nano Letters
[American Chemical Society]
日期:2021-11-03
卷期号:21 (22): 9410-9418
被引量:48
标识
DOI:10.1021/acs.nanolett.1c02582
摘要
By inducing tumor-specific immune responses, tumor vaccines have recently aroused great research interest. Herein, we design a targeted nanovaccine by equipping cell membrane vesicles (CMVs) harvested from tumor cells with functional DNA including CpG oligonucleotide, an agonist for toll-like receptor 9, as well as an aptamer targeting the dendritic cell (DC)-specific intercellular adhesion molecule (ICAM)-3 grabbing nonintegrin (DC-SIGN) receptor overexpressed on DCs. Such DNA-modified CMVs could target DCs and further stimulate their maturation. Notably, our nanovaccines could trigger robust antitumor immune responses to effective delay the tumor growth. Moreover, the combination of CMV-based nanovaccines with an immune checkpoint blockade could result in improved therapeutic responses by eliminating the majority of the tumors as well as long-term immune memory to prevent tumor recurrence. Therefore, by simply assembling functional DNA on CMVs harvested from tumor cells, we propose a general platform of DC-targeted personalized cancer vaccines for effective and specific cancer immunotherapy.
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