Determination of antioxidant migration levels from low-density polyethylene films into food simulants

An analytical method for the determination of specific migration levels of phenolic antioxidants from low-density polyethylene (LDPE) into food simulant has been developed. The screening and response surface experimental designs to optimize the liquid–liquid extraction (LLE) of these antioxidants have been tested and the analyses have been carried out by reversed-phase high-performance liquid chromatography (HPLC) coupled with ultraviolet diode-array detector. The procedure developed has been applied to specific migration tests in different commercial LDPE films. The considered antioxidants have not been found upper the legislation limits although Ethanox 330 and Irgafos 168 have been found at trace level.