Two new cytochalasins from an endophytic fungus, KL-1.1 isolated from Psidium guajava leaves

Chemical investigation of the endophytic fungus, KL-1.1, isolated from the leaves of Psidium guajava (Linn) led to the isolation of two new cytochalasin derivatives, 18-desoxy-19,20-epoxycytochalasin C and 18-desoxycytochalasin C, together with five other known derivatives. The structures of the isolated compounds were elucidated by one and two dimensional nuclear magnetic resonance spectroscopy as well as by mass spectrometry. These compounds represent novel chemical scaffold with potential for development into anticancer agents.