斑马鱼
生物
轴突引导
轴突
神经科学
神经系统
中枢神经系统
模型系统
发育生物学
胚胎干细胞
解剖
神经发育
细胞生物学
计算生物学
遗传学
基因
作者
Jensen T Hjorth,Brian Key
出处
期刊:PubMed
日期:2002-01-01
卷期号:46 (4): 609-19
被引量:53
摘要
The zebrafish has a number of distinct advantages as an experimental model in developmental biology. For example, large numbers of embryos can be generated in each lay, development proceeds rapidly through a very precise temporal staging which exhibits minimal batch-to-batch variability, embryos are transparent and imaging of wholemounts negates the need for tedious histological preparation while preserving three-dimensional spatial relationships. The zebrafish nervous system is proving a convenient model for studies of axon guidance because of its small size and highly stereotypical trajectory of axons. Moreover, a simple scaffold of axon tracts and nerves is established early and provides a template for subsequent development. The ease with which this template can be visualized as well as the ability to spatially resolve individual pioneer axons enables the role of specific cell-cell and molecular interactions to be clearly deciphered. We describe here the morphology and development of the earliest axon pathways in the embryonic zebrafish central nervous system and highlight the major questions that remain to be addressed with regard to axon guidance.
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