Microwave-assisted Aromatic C–O Bond Formation: A Rapid and Efficient Method for the Synthesis of Aryl Ethers

A rapid and efficient aromatic C–O bond formation has been developed based on microwave-assistant, which is particularly useful for the intramolecular coupling of halides with alcohols. This method needs not the use of transition-metal catalyst. It was also demonstrated that the method can be used in the synthesis of bioactive natural flavans.