Photopharmacology-based small-molecule proteolysis targeting chimeras: optical control of protein degradation

Future Medicinal ChemistryVol. 12, No. 22 EditorialPhotopharmacology-based small-molecule proteolysis targeting chimeras: optical control of protein degradationWen Li, Reham M Elhassan, Hao Fang & Xuben HouWen LiDepartment of Medicinal Chemistry & Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China, Reham M ElhassanDepartment of Medicinal Chemistry & Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China, Hao Fang*Author for correspondence: E-mail Address: haofangcn@sdu.edu.cnDepartment of Medicinal Chemistry & Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China & Xuben Hou **Author for correspondence: E-mail Address: hxb@sdu.edu.cnhttps://orcid.org/0000-0002-8346-9001Department of Medicinal Chemistry & Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, ChinaPublished Online:15 Oct 2020https://doi.org/10.4155/fmc-2020-0210AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: drug designphotopharmacologyPROTACprotein degradationReferences1. 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Chem. 63(9), 4644–4654 (2020).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByNovel Design Strategies to Enhance the Efficiency of Proteolysis Targeting Chimeras22 August 2022 | ACS Pharmacology & Translational Science, Vol. 5, No. 9Photocontrollable PROTAC molecules: Structure and mechanism of actionArhiv za farmaciju, Vol. 71, No. 3 Vol. 12, No. 22 Follow us on social media for the latest updates Metrics Downloaded 236 times History Received 30 June 2020 Accepted 24 August 2020 Published online 15 October 2020 Published in print November 2020 Information© 2020 Newlands PressKeywordsdrug designphotopharmacologyPROTACprotein degradationFinancial & competing interests disclosureThe financial support from the National Natural Science Foundation of China (nos. 81874288 and 21672127), Shandong Provincial Natural Science Foundation (no. ZR2019LZL004), the China-Australia Centre for Health Sciences Research (CACHSR no. 2019GJ07) and the Young Scholars Program of Shandong University. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download