癌变
转录组
致癌物
细胞
化学
癌症研究
表观遗传学
体外
小RNA
细胞生物学
毒性
转化(遗传学)
恶性转化
生物
生物化学
基因表达
基因
有机化学
作者
Sandra Ballesteros,Irene Barguilla,Ricard Marcos,Alba Hernández
出处
期刊:Nanomedicine
日期:2021-01-27
卷期号:16 (4): 293-305
被引量:7
标识
DOI:10.2217/nnm-2020-0367
摘要
Aim: To detect cell transformation effects of nanoceria after long-term exposure (up to 6 weeks) and to determine their potential interactions with cigarette smoke condensate, as a model of environmental carcinogenic pollutant. Materials & methods: Human bronchial epithelial BEAS-2 cells were used to determine transformation effects (invasion and tumorspheres induction), as well as changes in the expression of a battery of miRNAs related to the carcinogenesis process. Results: Nanoceria- and co-exposed cells exhibit cell transforming potential, with significantly increased invasion and tumorsphere formation abilities. Likewise, these exposures produced a high impact on the battery of miRNAs used. Conclusion: Nanoceria exposure induces cell-transformation and shows a positive interaction with the cell-transforming effects of cigarette smoke condensate. Besides, cerium dioxide nanoparticles and the co-exposure produced potential toxicity at the transcriptome level, which is related to tumorigenesis.
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