Jak Inhibitors Reverse Vitiligo in Mice but Do Not Deplete Skin Resident Memory T Cells

Vitiligo is an autoimmune skin disease presenting with distinct, patchy areas of depigmentation that can appear anywhere on the body. These white patches occur when autoreactive, cytotoxic CD8+ T cells promote the elimination of melanocytes, the pigment-producing cells of the epidermis (Frisoli et al., 2020). Vitiligo affects approximately 1% of the global population equally across races and sexes and frequently presents before the age of 20 years (Taïeb and Picardo, 2009).