Prognostic value of vascular endothelial growth factor in both conventional and drug eluting beads transarterial chemoembolization for treatment of unresectable hepatocellular carcinoma in HCV patients

医学 肝细胞癌 胃肠病学 内科学 肝硬化 血管内皮生长因子 经导管动脉化疗栓塞 进行性疾病 丙型肝炎病毒 血管内皮生长因子受体 化疗 病毒 免疫学
作者
Khaled Farid,Hatem Elalfy,Salwa M. Abo El‐khair,Hoda Elgamal,Tarek Besheer,Ali H. Elmokadem,Walaa Shabana,S. Abed,Mohamed Elegezy,Ahmed Abd El-Khalek,Ahmed Elmorsy,Amr Negm,Ayman Z. Elsamanoudy,Basem Eldeek,Talal Amer,Mahmoud El‐Bendary
出处
期刊:Expert Review of Gastroenterology & Hepatology [Taylor & Francis]
卷期号:14 (12): 1203-1214 被引量:17
标识
DOI:10.1080/17474124.2020.1823215
摘要

Objectives This work aimed to measure serum vascular endothelial growth factor (VEGF) levels before and after Conventional transarterial chemoembolization (cTACE) versus drug-eluting beads (DEB)-TACE and evaluate its efficacy in predicting response to therapy and tumor recurrence.Methods 114 patients with unresectable hepatocellular carcinoma complicating hepatitis C virus-related cirrhosis were included. They underwent cTACE (58) or DEB-TACE (56). VEGF serum levels were measured before and on days 1 and 30 after TACE. Patients with complete response (CR) after TACE were followed-up for one year. Statistical analysis was done.Results VEGF level was higher than baseline after cTACE (P < 0.001), and DEB-TACE (P = 0.004). It was also significantly higher in patients with progressive disease (P < 0.001). VEGF level at cut off values of 97.3, 149.8, and 104.1 pg/ml could discriminate disease progression from treatment success with area under ROC curves of 0.806, 0.775, and 0.771, respectively. The sensitivity was 88.9%, 88.9%, and 77.8% and specificity was 62.5%, 64.6 and 66.7%, respectively. However, no relation to tumor recurrence in CR group could be detected after one year.Conclusion VEGF serum levels may predict response to therapy in patients treated by DEB-TACE or cTACE but it has no relation to tumor recurrence.
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