小窝
黑素细胞
黑色素
细胞生物学
黑素体
细胞信号
细胞
角质形成细胞
细胞内
生物
表皮(动物学)
信号转导
细胞培养
解剖
癌症研究
生物化学
遗传学
黑色素瘤
作者
Lia Domingues,Ilse Hurbain,Floriane Gilles-Marsens,Julia Sirés-Campos,Nathalie André,Melissa Dewulf,Maryse Romao,Christine Viaris de Lesegno,Anne‐Sophie Macé,Cédric M. Blouin,Christelle Guéré,Katell Vié,Graça Raposo,Christophe Lamaze,Cédric Delevoye
标识
DOI:10.1038/s41467-020-16738-z
摘要
Abstract Tissue homeostasis requires regulation of cell–cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete factors transduced by melanocytes into signaling cues promoting their pigmentation and dendrite outgrowth, while melanocytes transfer melanin pigments to keratinocytes to convey skin photoprotection. How epidermal cells integrate these functions remains poorly characterized. Here, we show that caveolae are asymmetrically distributed in melanocytes and particularly abundant at the melanocyte–keratinocyte interface in epidermis. Caveolae in melanocytes are modulated by ultraviolet radiations and keratinocytes-released factors, like miRNAs. Preventing caveolae formation in melanocytes increases melanin pigment synthesis through upregulation of cAMP signaling and decreases cell protrusions, cell–cell contacts, pigment transfer and epidermis pigmentation. Altogether, we identify that caveolae serve as molecular hubs that couple signaling outputs from keratinocytes to mechanical plasticity of pigment cells. The coordination of intercellular communication and contacts by caveolae is thus crucial to skin pigmentation and tissue homeostasis.
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