脑出血
医学
跨细胞
缺血
内皮
内皮功能障碍
冲程(发动机)
内皮干细胞
神经科学
再灌注损伤
生物信息学
心脏病学
内科学
生物
蛛网膜下腔出血
体外
内吞作用
受体
工程类
机械工程
生物化学
作者
Anuska V. Andjelkovic,Jianming Xiang,Svetlana M. Stamatovic,Ya Hua,Guohua Xi,Michael M. Wang,Richard F. Keep
标识
DOI:10.1161/atvbaha.119.312816
摘要
Cerebral ischemia (stroke) induces injury to the cerebral endothelium that may contribute to parenchymal injury and worsen outcome. This review focuses on current preclinical studies examining how to prevent ischemia-induced endothelial dysfunction. It particularly focuses on targets at the endothelium itself. Those include endothelial tight junctions, transcytosis, endothelial cell death, and adhesion molecule expression. It also examines how such studies are being translated to the clinic, especially as adjunct therapies for preventing intracerebral hemorrhage during reperfusion of the ischemic brain. Identification of endothelial targets may prove valuable in a search for combination therapies that would specifically protect different cell types in ischemia.
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